Projects

Synthesis and Optimization for Emerging Technologies in Superconducting Electronics

(since 08/2020, PhD research)
Advisor: Professor Giovanni De Micheli, EPFL
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Scalable and Generic Logic Synthesis

(since 02/2020, PhD research)
Advisor: Professor Giovanni De Micheli, EPFL
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Threshold Logic Canonicalization and Weight-Sharing Synthesis

(08/2016 - 08/2019, bachelor special project)
Advisor: Professor Jie-Hong Roland Jiang, EE, NTU

The threshold logic (TL) function, parameterized by a vector of weights and a threshold value, is an important class of Boolean functions that imitate neural information processing. We devised a procedure to canonicalize a TL function such that two functions are equivalent if and only if their canonicalized linear inequalities are the same, and we studied the condition for a set of TL functions to be implementable with a common weight vector.

Related publications

• Siang-Yun Lee, Nian-Ze Lee, and Jie-Hong R. Jiang. “Searching Parallel Separating Hyperplanes for Effective Compression of Threshold Logic Networks,” 2019 IEEE/ACM International Conference on Computer-Aided Design (ICCAD). (IEEEXplore)
• Siang-Yun Lee, Nian-Ze Lee, and Jie-Hong R. Jiang. “Canonicalization of Threshold Logic Representation and Its Applications,” 2018 IEEE/ACM International Conference on Computer-Aided Design (ICCAD). (IEEEXplore)

Adaptive Reinforcement Learning on Navigational Task with Biological Model of Cognitive Spatial Map

(09/2019 - 01/2020, PhD semester project)
Advisor: Professor Wulfram Gerstner, EPFL

Modeling of The Spatial Perception System

(09/2017 - 01/2018, bachelor special project)
Advisor: Professor Shyh-Kang Jeng, EE, NTU

Mitochondrial Protein CYP11A1 Changes Mitochondrial Morphology

(01/2013 - 04/2015, high school special project)
Advisor: Professor Bon-Chu Chung, Academia Sinica, Taiwan

Mitochondria are the "energy factories" of the cell. Their main function is ATP production, and they are normally thumb-shaped with lamellar cristae. Mitochondrial morphology regulates apoptosis and autophagy, which are important in neurodegenerative diseases and cancer. CYP11A1 is a steroid-hormone-producing enzyme located in the inner mitochondrial membrane. The expression levels of CYP11A1 are also correlated with changes in mitochondrial morphology during cell differentiation. Therefore, my project aims to examine the hypothesis that CYP11A1 can change mitochondrial morphology. I conclude that CYP11A1 can change mitochondrial morphology and reduce ATP production rates whether with or without its activity. These results imply the relation between the "normal" changes of mitochondrial morphology and steroid hormone production.

Award earned

Fourth Award in cellular and molecular biology, Intel International Science and Engineering Fair (ISEF, Pittsburgh PA, USA), 05/2015.